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Title:

On the Pro-Metastatic Stress Response to Cancer Therapies: Evidence for a Positive Co-Operation between TIMP-1, HIF-1?, and miR-210.

Document type:
Journal Article
Author(s):
Cui, H; Grosso, S; Schelter, F; Mari, B; Kruger, A
Abstract:
In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad-spectrum inhibition of metalloproteinases can promote metastasis. In fact, malignant tumor cells, due to their genetic and epigenetic instability, are predisposed to react to stress by adaptation and, if the stress persists, by escape and formation of metastasis. Recent recognitio...     »
Journal title abbreviation:
Front Pharmacol
Year:
2012
Journal volume:
3
Pages contribution:
134
Language:
eng
Fulltext / DOI:
doi:10.3389/fphar.2012.00134
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22807917
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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