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Title:

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.

Document type:
Journal Article
Author(s):
Reinheckel, T; Peters, C; Kruger, A; Türk, B; Vasiljeva, O
Abstract:
Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progression remained unknown. By crossing various types of mouse cancer models with mice where specific cathepsins have been ablated, we contributed to this gap of knowledge and will summarize the results i...     »
Journal title abbreviation:
Front Pharmacol
Year:
2012
Journal volume:
3
Pages contribution:
133
Language:
eng
Fulltext / DOI:
doi:10.3389/fphar.2012.00133
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22798952
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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