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Title:

Site directed vascular gene delivery in vivo by ultrasonic destruction of magnetic nanoparticle coated microbubbles.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mannell, H; Pircher, J; Fochler, F; Stampnik, Y; Räthel, T; Gleich, B; Plank, C; Mykhaylyk, O; Dahmani, C; Wörnle, M; Ribeiro, A; Pohl, U; Krötz, F
Abstract:
Site specific vascular gene delivery for therapeutic implications is favorable because of reduction of possible side effects. Yet this technology faces numerous hurdles that result in low transfection rates because of suboptimal delivery. Combining ultrasonic microbubble technology with magnetic nanoparticle enhanced gene transfer could make it possible to use the systemic vasculature as the route of application and to magnetically trap these compounds at the target of interest. In this study we...     »
Journal title abbreviation:
Nanomedicine
Year:
2012
Journal volume:
8
Journal issue:
8
Pages contribution:
1309-18
Language:
eng
Fulltext / DOI:
doi:10.1016/j.nano.2012.03.007
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22480917
Print-ISSN:
1549-9634
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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