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Titel:

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.

Dokumenttyp:
Journal Article
Autor(en):
Reinheckel, T; Peters, C; Kruger, A; Türk, B; Vasiljeva, O
Abstract:
Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progression remained unknown. By crossing various types of mouse cancer models with mice where specific cathepsins have been ablated, we contributed to this gap of knowledge and will summarize the results i...     »
Zeitschriftentitel:
Front Pharmacol
Jahr:
2012
Band / Volume:
3
Seitenangaben Beitrag:
133
Sprache:
eng
Volltext / DOI:
doi:10.3389/fphar.2012.00133
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22798952
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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