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Titel:

Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Schäfer, H; Dieckmann, C; Korniienko, O; Moldenhauer, G; Kiefel, H; Salnikov, A; Kruger, A; Altevogt, P; Sebens, S
Abstract:
The adhesion molecule L1CAM (CD171) accounts for enhanced motility, invasiveness and chemoresistance of tumor cells and represents a novel marker for various tumor entities including pancreatic and ovarian carcinoma. Recently, we showed that L1CAM inhibition increases the apoptotic response of tumor cells towards cytostatic drugs pointing to the potential of L1CAM to serve as a chemosensitizer in anti-cancer therapy. Thus, the present study evaluated the therapeutic potential of combined treatme...     »
Zeitschriftentitel:
Cancer Lett
Jahr:
2012
Band / Volume:
319
Heft / Issue:
1
Seitenangaben Beitrag:
66-82
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.canlet.2011.12.035
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22210381
Print-ISSN:
0304-3835
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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