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Titel:

The P2 Receptor Antagonist PPADS Supports Recovery from Experimental Stroke In Vivo.

Dokumenttyp:
Journal Article; Article
Autor(en):
Lämmer, AB; Beck, A; Grummich, B; Förschler, A; Krügel, T; Kahn, T; Schneider, D; Illes, P; Franke, H; Krügel, U
Abstract:
After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y receptors.The effects of inhibition of P2 receptors by pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on electrophysiological, functional and morphological alterations in an ischemia model with permanent middle cerebral artery occlusion (MCAO...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2011
Band / Volume:
6
Heft / Issue:
5
Seitenangaben Beitrag:
e19983
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0019983
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21611146
Print-ISSN:
1932-6203
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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