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Titel:

Autophagy contributes to resistance of tumor cells to ionizing radiation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Chaachouay, H; Ohneseit, P; Toulany, M; Kehlbach, R; Multhoff, G; Rodemann, HP
Abstract:
Autophagy signaling is a novel important target to improve anticancer therapy. To study the role of autophagy on resistance of tumor cells to ionizing radiation (IR), breast cancer cell lines differing in their intrinsic radiosensitivity were used.Breast cancer cell lines MDA-MB-231 and HBL-100 were examined with respect to clonogenic cell survival and induction of autophagy after radiation exposure and pharmacological interference of the autophagic process. As marker for autophagy the appearanc...     »
Zeitschriftentitel:
Radiother Oncol
Jahr:
2011
Band / Volume:
99
Heft / Issue:
3
Seitenangaben Beitrag:
287-92
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.radonc.2011.06.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21722986
Print-ISSN:
0167-8140
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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