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Title:

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schildkopf, P; Frey, B; Ott, OJ; Rubner, Y; Multhoff, G; Sauer, R; Fietkau, R; Gaipl, US
Abstract:
Hyperthermia (HT) treatment of cancer patients was revived over the last years and has been proven to be beneficiary for many cancer entities when applied temperature controlled in multimodal treatments. We examined whether a combination of ionizing irradiation (X-ray) and HT (41.5°C; 1 h) can induce the release of heat shock protein (HSP) 70 by tumor cells and thereby lead to the activation of dendritic cells and macrophages.Extracellular HSP70 was detected in supernatants (SN) of treated colo...     »
Journal title abbreviation:
Radiother Oncol
Year:
2011
Journal volume:
101
Journal issue:
1
Pages contribution:
109-15
Language:
eng
Fulltext / DOI:
doi:10.1016/j.radonc.2011.05.056
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21704416
Print-ISSN:
0167-8140
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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