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Title:

Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.

Document type:
Journal Article
Author(s):
Schelter, F; Grandl, M; Seubert, B; Schaten, S; Hauser, S; Gerg, M; Boccaccio, C; Comoglio, P; Kruger, A
Abstract:
In many different tumor entities, increased expression of tissue inhibitor of metalloproteinases-1 (Timp-1) is associated with poor prognosis. We previously reported in mouse models that elevated systemic levels of Timp-1 induce a gene expression signature in the liver microenvironment increasing the susceptibility of this organ to tumor cells. This host effect was dependent on increased activity of the hepatocyte growth factor (Hgf)/hepatocyte growth factor receptor (Met) signaling pathway. In...     »
Journal title abbreviation:
Clin Exp Metastasis
Year:
2011
Journal volume:
28
Journal issue:
8
Pages contribution:
793-802
Language:
eng
Fulltext / DOI:
doi:10.1007/s10585-011-9410-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21789719
Print-ISSN:
0262-0898
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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