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Title:

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

Document type:
Article
Author(s):
Kilpelaeinen, TuomasO; Qi, Lu; Brage, Soren; Sharp, StephenJ; Sonestedt, Emily; Demerath, Ellen; Ahmad, Tariq; Mora, Samia; Kaakinen, Marika; Sandholt, CamillaHel; Holzapfel, Christina; Autenrieth, ChristineS; Hyppoenen, Elina; Cauchi, Stephane; He, Meian; Kutalik, Zoltan; Kumari, Meena; Stancakova, Alena; Meidtner, Karina; Balkau, Beverley; Tan, JonathanT; Mangino, Massimo; Timpson, NicholasJ; Song, Yiqing; Zillikens, MCarola; Jablonski, KathleenA; Garcia, MelissaE; Johansson, Stefan; Bragg-Gre...     »
Abstract:
Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). Methods and F...     »
Journal title abbreviation:
PLoS Med
Year:
2011
Journal volume:
8
Journal issue:
11
Pages contribution:
1-14
Language:
eng
Print-ISSN:
1549-1277
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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