Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.

Holzapfel, C; Siegrist, M; Rank, M; Langhof, H; Grallert, H; Baumert, J; Irimie, C; Klopp, N; Wolfarth, B; Illig, T; Hauner, H; Halle, M

doi:10.1530/EJE-10-0588

2011

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Titel:: Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.
Dokumenttyp:: Journal Article
Autor(en):: Holzapfel, C; Siegrist, M; Rank, M; Langhof, H; Grallert, H; Baumert, J; Irimie, C; Klopp, N; Wolfarth, B; Illig, T; Hauner, H; Halle, M
Abstract:: Genome-wide association studies have shown that the melatonin receptor 1B (MTNR1B) gene locus is strongly associated with fasting glucose and ?-cell function. However, data are rather limited to the adult population and normal-weight children. So far, little is known whether similar associations are present in overweight and obese children and adolescents.The aim is to investigate an MTNR1B polymorphism in a sample of 310 overweight and obese children and adolescents (mean body mass index standard deviation score (BMI-SDS)): 2.74 (± 0.55), mean age: 14 (± 2) years), who participated in a short-term weight-loss program based on energy reduction, physical activity, and behavior therapy.We investigated an association between genotype and fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and of ?-cell function (HOMA-B), and anthropometric parameters and their change during intervention.The minor G allele of polymorphism rs10830963 was significantly associated with increased fasting glucose (0.205 mmol/l, P<0.0001) and decreased HOMA-B (-0.353, P < 0.0001). Categorizing the sample into BMI-SDS groups, these significant associations were abolished in children with BMI-SDS below 2.5 but remained in those with higher BMI-SDS values with stronger ?-estimates. The P value for the genotype × BMI-SDS category interaction was 0.012 for fasting glucose and 0.083 for HOMA-B. There was no significant association between genotype and anthropometric parameters and their change during intervention.This is the first single study, replicating the association between the MTNR1B locus and diabetes-related traits in overweight and obese children and adolescents. The effect sizes in children and adolescents seem to be stronger than in adults and differed among BMI-SDS categories.
Zeitschriftentitel:: Eur J Endocrinol
Jahr:: 2011
Band / Volume:: 164
Heft / Issue:: 2
Seitenangaben Beitrag:: 205-12
Sprache:: eng
Volltext / DOI:: doi:10.1530/EJE-10-0588
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/21059861
Print-ISSN:: 0804-4643
TUM Einrichtung:: Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Poliklinik für Präventive und Rehabilitative Sportmedizin
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