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Titel:

Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo.

Dokumenttyp:
Journal Article
Autor(en):
Sato, S; Kopitz, C; Grismayer, B; Beaufort, N; Reuning, U; Schmitt, M; Luther, T; Kotzsch, M; Kruger, A; Magdolen, V
Abstract:
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice variants of this receptor have been reported. One of these, uPAR-del4/5, lacking exons 4 and 5, and thus encoding a uPAR form lacking domain DII, is specifically overexpressed in breast cancer and represents a statistically independent prognostic factor for distant metastasis-free survival in breast cancer patients. The aim of the present study was t...     »
Zeitschriftentitel:
Breast Cancer Res Treat
Jahr:
2011
Band / Volume:
127
Heft / Issue:
3
Seitenangaben Beitrag:
649-57
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10549-010-1042-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20635136
Print-ISSN:
0167-6806
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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