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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
von Holleben, M; Gohla, A; Janssen, KP; Iritani, BM; Beer-Hammer, S 
Title:
Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading. 
Abstract:
Appropriate B cell activation is essential for adaptive immunity. In contrast to the molecular mechanisms that regulate positive signaling in immune responses, the counterbalancing negative regulatory pathways remain insufficiently understood. The Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2 (SLy2, also known as hematopoietic adapter-containing SH3 and sterile ?-motif (SAM) domains 1; HACS1) is strongly up-regulated upon B cell activation and functions as an e...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2011 
Journal volume:
286 
Journal issue:
15 
Pages contribution:
13489-501 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-9258 
TUM Institution:
Chirurgische Klinik und Poliklinik