User: Guest  Login
Document type:
Journal Article 
Author(s):
Mutze, K; Langer, R; Schumacher, F; Becker, K; Ott, K; Novotny, A; Hapfelmeier, A; Höfler, H; Keller, G 
Title:
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer. 
Abstract:
DNA methylation contributes to carcinogenesis by mediating transcriptional regulation and chromatin remodelling, which may influence the effect of DNA-damaging drugs. We examined the prognostic and predictive impact of DNA methyltransferase (DNMT) 1 and 3b expression in gastric carcinomas (GC) treated by neoadjuvant chemotherapy. In vitro, DNMT1 expression and chemosensitivity were investigated for a functional relationship and the DNMT inhibitor decitabine (DAC) was tested as an alternative tre...    »
 
Journal title abbreviation:
Eur J Cancer 
Year:
2011 
Journal volume:
47 
Journal issue:
12 
Pages contribution:
1817-25 
Language:
eng 
Print-ISSN:
0959-8049 
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie