User: Guest  Login
Title:

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer.

Document type:
Journal Article
Author(s):
Künzli, BM; Bernlochner, MI; Rath, S; Käser, S; Csizmadia, E; Enjyoji, K; Cowan, P; d'Apice, A; Dwyer, K; Rosenberg, R; Perren, A; Friess, H; Maurer, CA; Robson, SC
Abstract:
Despite improvements in prevention and management of colorectal cancer (CRC), uncontrolled tumor growth with metastatic spread to distant organs remains an important clinical concern. Genetic deletion of CD39, the dominant vascular and immune cell ectonucleotidase, has been shown to delay tumor growth and blunt angiogenesis in mouse models of melanoma, lung and colonic malignancy. Here, we tested the influence of CD39 on CRC tumor progression and metastasis by investigating orthotopic transplant...     »
Journal title abbreviation:
Purinergic Signal
Year:
2011
Journal volume:
7
Journal issue:
2
Pages contribution:
231-41
Language:
eng
Fulltext / DOI:
doi:10.1007/s11302-011-9228-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21484085
Print-ISSN:
1573-9538
TUM Institution:
Chirurgische Klinik und Poliklinik
 BibTeX