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Dokumenttyp:
Journal Article
Autor(en):
Ceyhan, GO; Timm, AK; Bergmann, F; Günther, A; Aghdassi, AA; Demir, IE; Mayerle, J; Kern, M; Lerch, MM; Büchler, MW; Friess, H; Schemmer, P
Titel:
Prophylactic glycine administration attenuates pancreatic damage and inflammation in experimental acute pancreatitis.
Abstract:
Acute pancreatitis (AP) is characterized by premature zymogen activation, systemic inflammatory response resulting in inflammatory infiltrates, sustained intracellular calcium, neurogenic inflammation and pain. The inhibitory neurotransmitter and cytoprotective amino acid glycine exerts a direct inhibitory effect on inflammatory cells, inhibits calcium influx and neuronal activation and therefore represents a putative therapeutic agent in AP.To explore the impact of glycine, mild AP was induced...     »
Zeitschriftentitel:
Pancreatology
Jahr:
2011
Band / Volume:
11
Heft / Issue:
1
Seitenangaben Beitrag:
57-67
Sprache:
eng
Volltext / DOI:
doi:10.1159/000325972
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21474970
Print-ISSN:
1424-3903
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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