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Title:

Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases.

Document type:
Journal Article
Author(s):
Langer, R; Becker, K; Feith, M; Friess, H; Höfler, H; Keller, G
Abstract:
We present a series of 10 primary esophageal melanomas of Caucasian patients characterized clinicopathologically and on the molecular level. Mutation analysis for c-Kit (exons 9, 11, 13 and 17), PDGFR (exons 12, 14 and 18), NRAS and KRAS were determined using PCR and direct sequencing. Analysis of the V600E mutation of BRAF was performed using mutation-specific PCR. Expression of c-Kit and PDGFR-A was additionally determined using immunohistochemistry. One tumor harbored a missense mutation in t...     »
Journal title abbreviation:
Mod Pathol
Year:
2011
Journal volume:
24
Journal issue:
4
Pages contribution:
495-501
Language:
eng
Fulltext / DOI:
doi:10.1038/modpathol.2010.220
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21131919
Print-ISSN:
0893-3952
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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