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Titel:

Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
von Holleben, M; Gohla, A; Janssen, KP; Iritani, BM; Beer-Hammer, S
Abstract:
Appropriate B cell activation is essential for adaptive immunity. In contrast to the molecular mechanisms that regulate positive signaling in immune responses, the counterbalancing negative regulatory pathways remain insufficiently understood. The Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2 (SLy2, also known as hematopoietic adapter-containing SH3 and sterile ?-motif (SAM) domains 1; HACS1) is strongly up-regulated upon B cell activation and functions as an e...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2011
Band / Volume:
286
Heft / Issue:
15
Seitenangaben Beitrag:
13489-501
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M110.155184
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21296879
Print-ISSN:
0021-9258
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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