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Titel:

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
von Figura, G; Wagner, M; Nalapareddy, K; Hartmann, D; Kleger, A; Guachalla, LM; Rolyan, H; Adler, G; Rudolph, KL
Abstract:
Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.In...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2011
Band / Volume:
6
Heft / Issue:
2
Seitenangaben Beitrag:
e17122
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0017122
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21364961
Print-ISSN:
1932-6203
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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