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Title:

Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

Document type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Author(s):
Schürmann, B; Wiese, B; Bickel, H; Weyerer, S; Riedel-Heller, SG; Pentzek, M; Bachmann, C; Williams, J; van den Bussche, H; Maier, W; Jessen, F
Abstract:
A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy ind...     »
Journal title abbreviation:
J Alzheimers Dis
Year:
2011
Journal volume:
25
Journal issue:
3
Pages contribution:
421-4
Language:
eng
Fulltext / DOI:
doi:10.3233/JAD-2011-110251
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21422520
Print-ISSN:
1387-2877
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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