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Document type:
Journal Article
Author(s):
Laws, SM; Eckart, K; Friedrich, P; Kurz, A; Förstl, H; Riemenschneider, M
Title:
Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.
Abstract:
Cleavage of the amyloid precursor protein (APP) occurs through either an amyloidogenic or a non-amyloidogenic pathway. The first results in the generation of beta-amyloid (A?) and is initiated through cleavage by the beta-site amyloid beta A4 precursor protein-cleaving enzyme 1 (BACE1). The second precludes the formation of A? through cleavage by alpha-secretase, an enzyme's activity demonstrated in a disintegrin metalloproteinase, ADAM10. To assess the contribution of variants in the BACE1 and...     »
Journal title abbreviation:
Neurobiol Aging
Year:
2011
Journal volume:
32
Journal issue:
3
Pages contribution:
541-3
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neurobiolaging.2009.02.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19344981
Print-ISSN:
0197-4580
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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