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Titel:

Hippocampal volume differences between healthy young apolipoprotein E ?2 and ?4 carriers.

Dokumenttyp:
Journal Article; Article
Autor(en):
Alexopoulos, P; Richter-Schmidinger, T; Horn, M; Maus, S; Reichel, M; Sidiropoulos, C; Rhein, C; Lewczuk, P; Doerfler, A; Kornhuber, J
Abstract:
The apolipoprotein E (APOE) ?4 allele is the major genetic risk factor for the development of late-onset Alzheimer's disease (AD), whereas the presence of the APOE ?2 allele seems to confer protection. Here, we report that healthy young APOE ?4 carriers have statistically significantly smaller hippocampal volumes than APOE ?2 carriers, while no differences were detected between the two groups in memory performance. The difference in hippocampal morphology is cognitively/clinically silent in youn...     »
Zeitschriftentitel:
J Alzheimers Dis
Jahr:
2011
Band / Volume:
26
Heft / Issue:
2
Seitenangaben Beitrag:
207-10
Sprache:
eng
Volltext / DOI:
doi:10.3233/JAD-2011-110356
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21606569
Print-ISSN:
1387-2877
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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