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Title:

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Lübberstedt, M; Müller-Vieira, U; Mayer, M; Biemel, KM; Knöspel, F; Knobeloch, D; Nüssler, AK; Gerlach, JC; Zeilinger, K
Abstract:
Primary human hepatocytes are considered as a highly predictive in vitro model for preclinical drug metabolism studies. Due to the limited availability of human liver tissue for cell isolation, there is a need of alternative cell sources for pharmaceutical research.In this study, the metabolic activity and long-term stability of the human hepatoma cell line HepaRG were investigated in comparison to primary human hepatocytes (pHH). Hepatocyte-specific parameters (albumin and urea synthesis, galac...     »
Journal title abbreviation:
J Pharmacol Toxicol Methods
Year:
2011
Journal volume:
63
Journal issue:
1
Pages contribution:
59-68
Fulltext / DOI:
doi:10.1016/j.vascn.2010.04.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20460162
Print-ISSN:
1056-8719
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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