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Title:

The P2 Receptor Antagonist PPADS Supports Recovery from Experimental Stroke In Vivo.

Document type:
Journal Article; Article
Author(s):
Lämmer, AB; Beck, A; Grummich, B; Förschler, A; Krügel, T; Kahn, T; Schneider, D; Illes, P; Franke, H; Krügel, U
Abstract:
After ischemia of the CNS, extracellular adenosine 5'-triphosphate (ATP) can reach high concentrations due to cell damage and subsequent increase of membrane permeability. ATP may cause cellular degeneration and death, mediated by P2X and P2Y receptors.The effects of inhibition of P2 receptors by pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on electrophysiological, functional and morphological alterations in an ischemia model with permanent middle cerebral artery occlusion (MCAO...     »
Journal title abbreviation:
PLoS ONE
Year:
2011
Journal volume:
6
Journal issue:
5
Pages contribution:
e19983
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0019983
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21611146
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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