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Title:

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.

Document type:
Journal Article
Author(s):
Rasper, M; Schafer, A; Piontek, G; Teufel, J; Brockhoff, G; Ringel, F; Heindl, S; Zimmer, C; Schlegel, J
Abstract:
Glioblastoma (GBM) is the most aggressive primary brain tumor and is resistant to all therapeutic regimens. Relapse occurs regularly and might be caused by a poorly characterized tumor stem cell (TSC) subpopulation escaping therapy. We suggest aldehyde dehydrogenase 1 (ALDH1) as a novel stem cell marker in human GBM. Using the neurosphere formation assay as a functional method to identify brain TSCs, we show that high protein levels of ALDH1 facilitate neurosphere formation in established GBM ce...     »
Journal title abbreviation:
Neuro-oncol
Year:
2010
Journal volume:
12
Journal issue:
10
Pages contribution:
1024-33
Language:
eng
Fulltext / DOI:
doi:10.1093/neuonc/noq070
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20627895
Print-ISSN:
1522-8517
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Neurochirurgische Klinik und Poliklinik
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