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Titel:

Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Depboylu, C; Schorlemmer, K; Klietz, M; Oertel, WH; Weihe, E; Hoglinger, GU; Schäfer, MK
Abstract:
Here we analyzed C1q, the initial recognition subcomponent of classical complement activation cascade, in an experimental model of Parkinson disease (PD). Nigrostriatal dopaminergic pathway injury was induced by treatment of wildtype mice subchronically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Constitutive expression of C1q was restricted to microglia throughout the brain, and microglial C1q expression was early and transiently upregulated after MPTP in the substantia nigra (SN)...     »
Zeitschriftentitel:
J Neuroimmunol
Jahr:
2011
Band / Volume:
236
Heft / Issue:
1-2
Seitenangaben Beitrag:
39-46
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jneuroim.2011.05.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21640391
Print-ISSN:
0165-5728
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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