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Title:

Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stamelou, M; Christ, H; Reuss, A; Oertel, W; Höglinger, G
Abstract:
The objective of this study was to evaluate whether the sensation of thirst differs between patients with progressive supranuclear palsy (PSP), multiple system atrophy with predominant parkinsonism (MSA-P), and Parkinson's disease (PD).We administered a standardized thirst questionnaire to age-, sex-, and stage-matched patients with probable PSP, PD, and MSA-P and healthy controls (HC), n = 15/group. In an independent cohort (n = 10/group), we provoked thirst by infusing hypertonic NaCl in age-, sex-, and stage-matched patients with PSP, PD, and MSA-P and recorded plasma osmolality and thirst (visual analog scale).On questioning, 73% of PSP patients reported a reduced sensation of thirst (hypodipsia) compared with previous years (HC, 0%; PD, 7%; MSA-P, 7%; P < .0001). On NaCl infusion, PSP patients reported significantly lower thirst than did PD and MSA-P patients for all times from 20 to 95 minutes (P < .05). The thirst score at 25 minutes discriminated individual PSP patients well from PD and MSA-P patients.Hypodipsia appears helpful in differentiating PSP from PD and MSA-P.
Journal title abbreviation:
Mov Disord
Year:
2011
Journal volume:
26
Journal issue:
5
Pages contribution:
901-5
Language:
eng
Fulltext / DOI:
doi:10.1002/mds.23587
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21384428
Print-ISSN:
0885-3185
TUM Institution:
Neurologische Klinik und Poliklinik
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