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Titel:

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ros-Bernal, F; Hunot, S; Herrero, MT; Parnadeau, S; Corvol, JC; Lu, L; Alvarez-Fischer, D; Carrillo-de Sauvage, MA; Saurini, F; Coussieu, C; Kinugawa, K; Prigent, A; Höglinger, G; Hamon, M; Tronche, F; Hirsch, EC; Vyas, S
Abstract:
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pathological states. We examined the role of glucocorticoid receptors (GRs), activated by glucocorticoids released in response to stress and known to regulate inflammation, in DN surv...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2011
Band / Volume:
108
Heft / Issue:
16
Seitenangaben Beitrag:
6632-7
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1017820108
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21467220
Print-ISSN:
0027-8424
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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