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Title:

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Ros-Bernal, F; Hunot, S; Herrero, MT; Parnadeau, S; Corvol, JC; Lu, L; Alvarez-Fischer, D; Carrillo-de Sauvage, MA; Saurini, F; Coussieu, C; Kinugawa, K; Prigent, A; Höglinger, G; Hamon, M; Tronche, F; Hirsch, EC; Vyas, S
Abstract:
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pathological states. We examined the role of glucocorticoid receptors (GRs), activated by glucocorticoids released in response to stress and known to regulate inflammation, in DN surv...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2011
Journal volume:
108
Journal issue:
16
Pages contribution:
6632-7
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1017820108
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21467220
Print-ISSN:
0027-8424
TUM Institution:
Neurologische Klinik und Poliklinik
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