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Title:

Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats.

Document type:
Journal Article
Author(s):
Füchtemeier, M; Leithner, C; Offenhauser, N; Foddis, M; Kohl-Bareis, M; Dirnagl, U; Lindauer, U; Royl, G
Abstract:
BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling. To date, it is unclear whether intracranial pressure (ICP) modifies deoxy-Hb signaling for brain mapping. In addition, ICP elevation can test whether the BOLD post-stimulus undershoot, a transient hypo-oxygenation following functional activation, is due to vascular compliance rather than elevated cerebral metabolic rate of oxygen (CMRO(2)). We addressed these q...     »
Journal title abbreviation:
Neuroimage
Year:
2010
Journal volume:
52
Journal issue:
2
Pages contribution:
445-54
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuroimage.2010.04.237
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20420930
Print-ISSN:
1053-8119
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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