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Titel:

Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats.

Dokumenttyp:
Journal Article
Autor(en):
Füchtemeier, M; Leithner, C; Offenhauser, N; Foddis, M; Kohl-Bareis, M; Dirnagl, U; Lindauer, U; Royl, G
Abstract:
BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling. To date, it is unclear whether intracranial pressure (ICP) modifies deoxy-Hb signaling for brain mapping. In addition, ICP elevation can test whether the BOLD post-stimulus undershoot, a transient hypo-oxygenation following functional activation, is due to vascular compliance rather than elevated cerebral metabolic rate of oxygen (CMRO(2)). We addressed these q...     »
Zeitschriftentitel:
Neuroimage
Jahr:
2010
Band / Volume:
52
Heft / Issue:
2
Seitenangaben Beitrag:
445-54
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.neuroimage.2010.04.237
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20420930
Print-ISSN:
1053-8119
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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