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Titel:

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Yasuno, K; Bilguvar, K; Bijlenga, P; Low, SK; Krischek, B; Auburger, G; Simon, M; Krex, D; Arlier, Z; Nayak, N; Ruigrok, YM; Niemelä, M; Tajima, A; von und zu Fraunberg, M; Dóczi, T; Wirjatijasa, F; Hata, A; Blasco, J; Oszvald, A; Kasuya, H; Zilani, G; Schoch, B; Singh, P; Stüer, C; Risselada, R; Beck, J; Sola, T; Ricciardi, F; Aromaa, A; Illig, T; Schreiber, S; van Duijn, CM; Van den Berg, LH; Perret, C; Proust, C; Röder, C; Ozturk, AK; Gaál, E; Berg, D; Geisen, C; Friedrich, CM; Summers, P; Fr...     »
Abstract:
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysm...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2010
Band / Volume:
42
Heft / Issue:
5
Seitenangaben Beitrag:
420-5
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.563
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20364137
Print-ISSN:
1061-4036
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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