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Titel:

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.

Dokumenttyp:
Journal Article
Autor(en):
Rasper, M; Schafer, A; Piontek, G; Teufel, J; Brockhoff, G; Ringel, F; Heindl, S; Zimmer, C; Schlegel, J
Abstract:
Glioblastoma (GBM) is the most aggressive primary brain tumor and is resistant to all therapeutic regimens. Relapse occurs regularly and might be caused by a poorly characterized tumor stem cell (TSC) subpopulation escaping therapy. We suggest aldehyde dehydrogenase 1 (ALDH1) as a novel stem cell marker in human GBM. Using the neurosphere formation assay as a functional method to identify brain TSCs, we show that high protein levels of ALDH1 facilitate neurosphere formation in established GBM ce...     »
Zeitschriftentitel:
Neuro-oncol
Jahr:
2010
Band / Volume:
12
Heft / Issue:
10
Seitenangaben Beitrag:
1024-33
Sprache:
eng
Volltext / DOI:
doi:10.1093/neuonc/noq070
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20627895
Print-ISSN:
1522-8517
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Neurochirurgische Klinik und Poliklinik
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