High-sensitivity troponin T level and angiographic severity of coronary artery disease.

Ndrepepa, G; Braun, S; Schulz, S; Mehilli, J; Schömig, A; Kastrati, A

doi:10.1016/j.amjcard.2011.04.012

2011

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Title:: High-sensitivity troponin T level and angiographic severity of coronary artery disease.
Document type:: Journal Article
Author(s):: Ndrepepa, G; Braun, S; Schulz, S; Mehilli, J; Schömig, A; Kastrati, A
Abstract:: The association between circulating levels of cardiac troponins and angiographic severity of coronary artery disease (CAD) has not been studied. We investigated whether there is an association between the level of high-sensitivity troponin T (hs-TnT) and angiographic severity of CAD and whether this association is independent of conventional risk factors, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and C-reactive protein (CRP). This case-control study included 904 patients with stable CAD (cases) and 412 patients with chest pain but without significant CAD on coronary angiogram (controls). Diagnosis of CAD was confirmed or excluded by coronary angiography. Cardiac TnT was measured with conventional and high-sensitivity assays in parallel using the same plasma sample. In patients with no CAD and in those with 1-, 2-, or 3-vessel disease, hs-TnT levels (median, twenty-fifth to seventy-fifth percentiles) were 0.005 ?g/L (<0.003 to 0.009), 0.006 ?g/L (0.003 to 0.011), 0.008 ?g/L (0.004 to 0.013), and 0.010 ?g/L (0.006 to 0.017), respectively (p <0.001). In multivariable analysis adjusting for cardiovascular risk factors and clinical variables including NT-pro-BNP and CRP, hs-TnT was an independent predictor of presence of CAD (adjusted odds ratio 1.30, 95% confidence interval 1.07 to 1.59, p = 0.009). In conclusion, in patients with stable and angiographically proved CAD, hs-TnT level is increased compared to subjects without CAD and correlates with angiographic atherosclerotic extent and burden. The association between increased levels of hs-TnT and presence of CAD was independent of traditional cardiovascular risk factors, NT-pro-BNP, and CRP.
Journal title abbreviation:: Am J Cardiol
Year:: 2011
Journal volume:: 108
Journal issue:: 5
Pages contribution:: 639-43
Language:: eng
Fulltext / DOI:: doi:10.1016/j.amjcard.2011.04.012
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/21676369
Print-ISSN:: 0002-9149
TUM Institution:: I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder)2011

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2011