Multicenter evaluation of a new automated electrochemiluminescence immunoassay for the quantification of testosterone compared to liquid chromatography tandem mass spectrometry.

Brandhorst, G; Streit, F; Kratzsch, J; Schiettecatte, J; Roth, HJ; Luppa, PB; Körner, A; Kiess, W; Binder, L; Oellerich, M; von Ahsen, N

doi:10.1016/j.clinbiochem.2010.09.024

2011

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Title:: Multicenter evaluation of a new automated electrochemiluminescence immunoassay for the quantification of testosterone compared to liquid chromatography tandem mass spectrometry.
Document type:: Journal Article
Author(s):: Brandhorst, G; Streit, F; Kratzsch, J; Schiettecatte, J; Roth, HJ; Luppa, PB; Körner, A; Kiess, W; Binder, L; Oellerich, M; von Ahsen, N
Abstract:: A new electrochemiluminescence testosterone immunoassay (Elecsys® Testo II) was evaluated.Within-run precision, total precision, and method comparisons to the former immunoassay and LC-MS/MS were investigated. Reference intervals were established for adults and children.Imprecision ranged from 0.9% to 8.5%. Method comparisons revealed slopes from 0.68 to 1.32 and coefficients of correlation from 0.893 to 0.991.Improved agreement with LC-MS/MS was demonstrated, especially for female patients. The assay may be a suitable alternative for laboratories with no access to MS techniques. «
A new electrochemiluminescence testosterone immunoassay (Elecsys® Testo II) was evaluated.Within-run precision, total precision, and method comparisons to the former immunoassay and LC-MS/MS were investigated. Reference intervals were established for adults and children.Imprecision ranged from 0.9% to 8.5%. Method comparisons revealed slopes from 0.68 to 1.32 and coefficients of correlation from 0.893 to 0.991.Improved agreement with LC-MS/MS was demonstrated, especially for female patients. The... »
Journal title abbreviation:: Clin Biochem
Year:: 2011
Journal volume:: 44
Journal issue:: 2-3
Pages contribution:: 264-7
Language:: eng
Fulltext / DOI:: doi:10.1016/j.clinbiochem.2010.09.024
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20923677
Print-ISSN:: 0009-9120
TUM Institution:: Institut für Klinische Chemie und Pathobiochemie
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mediaTUM Gesamtbestand Hochschulbibliographie 2011 Fakultäten Medizin Institut für Klinische Chemie und Pathobiochemie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)2011