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Title:

The effect of treatment with ketoconazole on central CRH systems of depressed patients.

Document type:
Journal Article
Author(s):
Paslakis, G; Lecei, O; Stalla, GK; Landgraf, R; Uhr, M; Hamann, B; Luppa, P; Gilles, M; Heuser, I; Deuschle, M
Abstract:
Steroid-synthesis inhibitors are reported to reduce psychopathology in treatment-resistant depressed patients.We studied the effect of a 3-week treatment with ketoconazole on the evening plasma concentrations of cortisol, corticosteroid-binding globulin (CBG), dehydroepiandrosterone-sulfate (DHEA-S) and adrenocorticotrope hormone (ACTH) as well as morning cerebrospinal fluid (CSF) concentrations of cortisol, corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP) in six elderly trea...     »
Journal title abbreviation:
Hum Psychopharmacol
Year:
2011
Journal volume:
26
Journal issue:
1
Pages contribution:
35-40
Language:
eng
Fulltext / DOI:
doi:10.1002/hup.1167
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21394787
Print-ISSN:
0885-6222
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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