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Titel:

Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome.

Dokumenttyp:
Journal Article; Article
Autor(en):
Laika, B; Leucht, S; Heres, S; Schneider, H; Steimer, W
Abstract:
Psychiatric pharmacotherapy with olanzapine is commonplace. We investigated the influence of CYP1A2*1F (-163A, rs762551) and serotonergic polymorphisms on olanzapine serum concentrations and clinical outcome in a naturalistic clinical setting. Included were 124 Caucasian psychiatric inpatients treated with olanzapine for at least 4 weeks with steady-state serum concentrations available for 73 patients. The CYP1A2*1F polymorphism was reported to affect the inducibility of CYP1A2. In our study pop...     »
Zeitschriftentitel:
Pharmacogenomics J
Jahr:
2010
Band / Volume:
10
Heft / Issue:
1
Seitenangaben Beitrag:
20-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/tpj.2009.32
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19636338
Print-ISSN:
1470-269X
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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