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Title:

Pancreatic cancers require autophagy for tumor growth.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Yang, S; Wang, X; Contino, G; Liesa, M; Sahin, E; Ying, H; Bause, A; Li, Y; Stommel, JM; Dell'antonio, G; Mautner, J; Tonon, G; Haigis, M; Shirihai, OS; Doglioni, C; Bardeesy, N; Kimmelman, AC
Abstract:
Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and may differ depending on tumor type or context. Here we show that pancreatic cancers have a distinct dependence on autophagy. Pancreatic cancer primary tumors and cell lines show elevated autophagy under basal conditions. Genetic or pharmacologic inhibition of autophagy leads to increased reactive oxygen species, elevated DNA damage, and a m...     »
Journal title abbreviation:
Genes Dev
Year:
2011
Journal volume:
25
Journal issue:
7
Pages contribution:
717-29
Language:
eng
Fulltext / DOI:
doi:10.1101/gad.2016111
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21406549
Print-ISSN:
0890-9369
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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