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Titel:

Pancreatic cancers require autophagy for tumor growth.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Yang, S; Wang, X; Contino, G; Liesa, M; Sahin, E; Ying, H; Bause, A; Li, Y; Stommel, JM; Dell'antonio, G; Mautner, J; Tonon, G; Haigis, M; Shirihai, OS; Doglioni, C; Bardeesy, N; Kimmelman, AC
Abstract:
Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and may differ depending on tumor type or context. Here we show that pancreatic cancers have a distinct dependence on autophagy. Pancreatic cancer primary tumors and cell lines show elevated autophagy under basal conditions. Genetic or pharmacologic inhibition of autophagy leads to increased reactive oxygen species, elevated DNA damage, and a m...     »
Zeitschriftentitel:
Genes Dev
Jahr:
2011
Band / Volume:
25
Heft / Issue:
7
Seitenangaben Beitrag:
717-29
Sprache:
eng
Volltext / DOI:
doi:10.1101/gad.2016111
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21406549
Print-ISSN:
0890-9369
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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