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Title:

Prediction and pathogenesis in type 1 diabetes.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Review; Review
Author(s):
Ziegler, AG; Nepom, GT
Abstract:
A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical phase of disease to end-stage islet damage, with biomarkers indicating transition from susceptibility to active autoimmunity, and to a final loss of immune regulation. Here, we review the markers that provide evidence for immunological checkpoint failure and that also provide tools for assessment of individualized diseas...     »
Journal title abbreviation:
Immunity
Year:
2010
Journal volume:
32
Journal issue:
4
Pages contribution:
468-78
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2010.03.018
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20412757
Print-ISSN:
1074-7613
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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