Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws.

Mücke, T; Koschinski, J; Deppe, H; Wagenpfeil, S; Pautke, C; Mitchell, DA; Wolff, KD; Hölzle, F

doi:10.1007/s00432-010-0953-1

journal article

Document type:: Journal Article
Author(s):: Mücke, T; Koschinski, J; Deppe, H; Wagenpfeil, S; Pautke, C; Mitchell, DA; Wolff, KD; Hölzle, F
Title:: Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws.
Abstract:: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is now a well-recognised entity which is difficult to manage and often recurs. The aim of this study was to examine the success of resection of the necrotic bone and identify risk factors for recurrence in these patients.One hundred and eight patients were evaluated prospectively and investigated at least twice. Multiple logistic regression analysis was used to determine factors independently associated with the dependent variable of recurrence of BRONJ.Factors influencing the development of recurrence of BRONJ were the presence of bacterial bone infection of the necrotic area (P = 0.011), type of treatment (either conservative or surgical, P = 0.001) with a lower recurrence rate for surgically treated patients, extent of surgical treatment with better outcome in larger resections (P < 0.0001), number of debridements performed (P < 0.0001), and the extent of radiographic appearance of osteolysis assessed by dental panoramic tomogram (P = 0.028).An increased risk for recurrence can be found in cases with bacterial bone infection of the necrotic area, type of conservative or surgical treatment, extent of surgical treatment with better outcome in larger resections, and the number of debridements performed. Microvascular tissue transfer should be considered in selected cases if other options have been exhausted.
Journal title abbreviation:: J Cancer Res Clin Oncol
Year:: 2011
Journal volume:: 137
Journal issue:: 5
Pages contribution:: 907-13
Language:: eng
Fulltext / DOI:: doi:10.1007/s00432-010-0953-1
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20927569
Print-ISSN:: 0171-5216
TUM Institution:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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