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Title:

Phosphodiesterase 10A in the rat pineal gland: localization, daily and seasonal regulation of expression and influence on signal transduction.

Document type:
Journal Article
Author(s):
Spiwoks-Becker, I; Wolloscheck, T; Rickes, O; Kelleher, DK; Rohleder, N; Weyer, V; Spessert, R
Abstract:
The cyclic nucleotide phosphodiesterase 10A (PDE10A) is highly expressed in striatal spiny projection neurons and represents a therapeutic target for the treatment of psychotic symptoms. As reported previously [J Biol Chem 2009; 284:7606-7622], in this study PDE10A was seen to be additionally expressed in the pineal gland where the levels of PDE10A transcript display daily changes. As with the transcript, the amount of PDE10A protein was found to be under daily and seasonal regulation. The obse...     »
Journal title abbreviation:
Neuroendocrinology
Year:
2011
Journal volume:
94
Journal issue:
2
Pages contribution:
113-23
Language:
eng
Fulltext / DOI:
doi:10.1159/000327138
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21474921
Print-ISSN:
0028-3835
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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