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Title:

The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia.

Document type:
Journal Article
Author(s):
Dallmann, R; Weyermann, P; Anklin, C; Boroff, M; Bray-French, K; Cardel, B; Courdier-Fruh, I; Deppe, H; Dubach-Powell, J; Erb, M; Haefeli, RH; Henneböhle, M; Herzner, H; Hufschmid, M; Marks, DL; Nordhoff, S; Papp, M; Rummey, C; Santos, G; Schärer, F; Siendt, H; Soeberdt, M; Sumanovski, LT; Terinek, M; Mondadori, C; Güven, N; Feurer, A
Abstract:
BACKGROUND: Under physiological conditions, the melanocortin system is a crucial part of the complex network regulating food intake and energy expenditure. In pathological states, like cachexia, these two parameters are deregulated, i.e., food intake is decreased and energy expenditure is increased-a vicious combination leading to catabolism. Agouti-related protein (AgRP), the endogenous antagonist at the melanocortin-4 receptor (MC-4R), was found to increase food intake and to reduce energy exp...     »
Journal title abbreviation:
J Cachexia Sarcopenia Muscle
Year:
2011
Journal volume:
2
Journal issue:
3
Pages contribution:
163-174
Language:
eng
Fulltext / DOI:
doi:10.1007/s13539-011-0039-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21966642
Print-ISSN:
2190-5991
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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