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Titel:

The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia.

Dokumenttyp:
Journal Article
Autor(en):
Dallmann, R; Weyermann, P; Anklin, C; Boroff, M; Bray-French, K; Cardel, B; Courdier-Fruh, I; Deppe, H; Dubach-Powell, J; Erb, M; Haefeli, RH; Henneböhle, M; Herzner, H; Hufschmid, M; Marks, DL; Nordhoff, S; Papp, M; Rummey, C; Santos, G; Schärer, F; Siendt, H; Soeberdt, M; Sumanovski, LT; Terinek, M; Mondadori, C; Güven, N; Feurer, A
Abstract:
BACKGROUND: Under physiological conditions, the melanocortin system is a crucial part of the complex network regulating food intake and energy expenditure. In pathological states, like cachexia, these two parameters are deregulated, i.e., food intake is decreased and energy expenditure is increased-a vicious combination leading to catabolism. Agouti-related protein (AgRP), the endogenous antagonist at the melanocortin-4 receptor (MC-4R), was found to increase food intake and to reduce energy exp...     »
Zeitschriftentitel:
J Cachexia Sarcopenia Muscle
Jahr:
2011
Band / Volume:
2
Heft / Issue:
3
Seitenangaben Beitrag:
163-174
Sprache:
eng
Volltext / DOI:
doi:10.1007/s13539-011-0039-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21966642
Print-ISSN:
2190-5991
TUM Einrichtung:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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