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Title:

Gentamycin delivered from a PDLLA coating of metallic implants In vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis

Document type:
Article
Author(s):
Vester, H; Wildemann, B; Schmidmaier, G; Stöckle, U; Lucke, M
Abstract:
Locally applied antibiotics support prophylaxis of highly feared implant associated infections. Implant coatings with poly(D, L-lactide) (PDLLA)/gentamicin seem to be a promising approach. Aims of this study were to analyse the release kinetics of gentamicin in vivo, in vitro, to analyse the antibacterial efficacy, the resistance development and its impact on osteoblasts. For the in vitro release experiments titanium implants were coated with PDLLA/gentamicin and the antibiotic release in aqueou...     »
Journal title abbreviation:
Injury
Year:
2010
Journal volume:
41
Journal issue:
10
Pages contribution:
1053-1059
Print-ISSN:
0020-1383
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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