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Title:

Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Seehofer, D; Schirmeier, A; Bengmark, S; Cho, SY; Koch, M; Lederer, A; Rayes, N; Menger, MD; Neuhaus, P; Nüssler, AK
Abstract:
Curcumin is a nontoxic, hepatoprotective antioxidant. It has been shown to efficiently scavenge oxygen free radicals, increase intracellular glutathione concentrations, and prevent lipid peroxidation in rat hepatocytes. Moreover, it has strong anti-inflammatory effects. In the present study we assessed its effect in a model of liver regeneration impaired by bacterial infections.Male Sprague-Dawley rats underwent sham operation, cecal ligation and puncture (CLP), synchronous partial hepatectomy (...     »
Journal title abbreviation:
J Surg Res
Year:
2010
Journal volume:
159
Journal issue:
1
Pages contribution:
497-502
Fulltext / DOI:
doi:10.1016/j.jss.2008.12.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19321178
Print-ISSN:
0022-4804
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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