Benutzer: Gast  Login
Titel:

Neohepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-beta/Smad3 signaling: advantage for cell transplantation?

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ehnert, S; Knobeloch, D; Blankenstein, A; Müller, A; Böcker, U; Gillen, S; Friess, H; Thasler, WE; Dooley, S; Nüssler, AK
Abstract:
BACKGROUND: Liver transplantation is the only definitive treatment for end stage liver disease. Donor organ scarcity raises a growing interest in new therapeutic options. Recently, we have shown that injection of monocyte-derived NeoHepatocytes can increase survival in rats with extended liver resection. In order to apply this technology in humans with chronic liver diseases in an autologous setting, we generated NeoHepatocytes from patients with alcoholic liver disease and healthy controls and...     »
Zeitschriftentitel:
Alcohol Clin Exp Res
Jahr:
2010
Band / Volume:
34
Heft / Issue:
4
Seitenangaben Beitrag:
708-18
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1530-0277.2009.01140.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20102559
Print-ISSN:
0145-6008
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Klinik und Poliklinik für Unfallchirurgie
 BibTeX