Tumor shrinkage assessed by volumetric MRI in the long-term follow-up after stereotactic radiotherapy of meningiomas.

Astner, ST; Theodorou, M; Dobrei-Ciuchendea, M; Auer, F; Kopp, C; Molls, M; Grosu, AL

doi:10.1007/s00066-010-2138-x

2010

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Dokumenttyp:: Journal Article
Autor(en):: Astner, ST; Theodorou, M; Dobrei-Ciuchendea, M; Auer, F; Kopp, C; Molls, M; Grosu, AL
Titel:: Tumor shrinkage assessed by volumetric MRI in the long-term follow-up after stereotactic radiotherapy of meningiomas.
Abstract:: PURPOSE: To evaluate tumor volume reduction in the follow-up of meningiomas after fractionated stereotactic radiotherapy (FSRT) or linac radiosurgery (RS) by using magnetic resonance imaging (MRI). PATIENTS AND METHODS: In 59 patients with skull base meningiomas, gross tumor volume (GTV) was outlined on contrast-enhanced MRI before and median 50 months (range 11-92 months) after stereotactic radiotherapy. MRI was performed as an axial three-dimensional gradient-echo T1-weighted sequence at 1.6 mm slice thickness without gap (3D-MRI). Results were compared to the reports of diagnostic findings. RESULTS: Mean tumor size of all 59 meningiomas was 13.9 ml (0.8-62.9 ml) before treatment. There was shrinkage of the treated meningiomas in all but one patient. Within a median volumetric follow-up of 50 months (11-95 months), an absolute mean volume reduction of 4 ml (0-18 ml) was seen. The mean relative size reduction compared to the volume before radiotherapy was 27% (0-73%). Shrinkage measured by 3D-MRI was greater at longer time intervals after radiotherapy. The mean size reduction was 17%, 23%, and 30% (at < 24 months, 24-48 months, and 48-72 months). CONCLUSION: By using 3D-MRI in almost all patients undergoing radiotherapy of a meningioma, tumor shrinkage is detected. The data presented here demonstrate that volumetric assessment from 3D-MRI provides additional information to routinely used radiologic response measurements. After FSRT or RS, a mean size reduction of 25-45% can be expected within 4 years.
Zeitschriftentitel:: Strahlenther Onkol
Jahr:: 2010
Band / Volume:: 186
Heft / Issue:: 8
Seitenangaben Beitrag:: 423-9
Sprache:: eng
Volltext / DOI:: doi:10.1007/s00066-010-2138-x
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/20803282
Print-ISSN:: 0179-7158
TUM Einrichtung:: Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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