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Titel:

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Elsner, L; Flügge, PF; Lozano, J; Muppala, V; Eiz-Vesper, B; Demiroglu, SY; Malzahn, D; Herrmann, T; Brunner, E; Bickeböller, H; Multhoff, G; Walter, L; Dressel, R
Abstract:
Although natural killer (NK) cells are often described as first line defence against infected or malignant cells which act without the need of prior activation, it is known now that the NK cell activity is tightly regulated by other cells and soluble factors. We show here that the stress-inducible heat shock protein (HSP) 70 activates human NK cells to kill target cells expressing major histocompatibility complex class I chain-related molecule A (MICA) in a natural killer group 2 member D (NKG2D...     »
Zeitschriftentitel:
J Cell Mol Med
Jahr:
2010
Band / Volume:
14
Heft / Issue:
4
Seitenangaben Beitrag:
992-1002
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1582-4934.2009.00677.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20569278
Print-ISSN:
1582-1838
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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