Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Hollingworth, P; Harold, D; Sims, R; Gerrish, A; Lambert, JC; Carrasquillo, MM; Abraham, R; Hamshere, ML; Pahwa, JS; Moskvina, V; Dowzell, K; Jones, N; Stretton, A; Thomas, C; Richards, A; Ivanov, D; Widdowson, C; Chapman, J; Lovestone, S; Powell, J; Proitsi, P; Lupton, MK; Brayne, C; Rubinsztein, DC; Gill, M; Lawlor, B; Lynch, A; Brown, KS; Passmore, PA; Craig, D; McGuinness, B; Todd, S; Holmes, C; Mann, D; Smith, AD; Beaumont, H; Warden, D; Wilcock, G; Love, S; Kehoe, PG; Hooper, NM; Vardy, ER; Hardy, J; Mead, S; Fox, NC; Rossor, M; Collinge, J; Maier, W; Jessen, F; Ruther, E; Schürmann, B; Heun, R; Kölsch, H; van den Bussche, H; Heuser, I; Kornhuber, J; Wiltfang, J; Dichgans, M; Frölich, L; Hampel, H; Gallacher, J; Hüll, M; Rujescu, D; Giegling, I; Goate, AM; Kauwe, JS; Cruchaga, C; Nowotny, P; Morris, JC; Mayo, K; Sleegers, K; Bettens, K; Engelborghs, S; De Deyn, PP; Van Broeckhoven, C; Livingston, G; Bass, NJ; Gurling, H; McQuillin, A; Gwilliam, R; Deloukas, P; Al-Chalabi, A; Shaw, CE; Tsolaki, M; Singleton, AB; Guerreiro, R; Mühleisen, TW; Nöthen, MM; Moebus, S; Jöckel, KH; Klopp, N; Wichmann, HE; Pankratz, VS; Sando, SB; Aasly, JO; Barcikowska, M; Wszolek, ZK; Dickson, DW; Graff-Radford, NR; Petersen, RC; van Duijn, CM; Breteler, MM; Ikram, MA; DeStefano, AL; Fitzpatrick, AL; Lopez, O; Launer, LJ; Seshadri, S; Berr, C; Campion, D; Epelbaum, J; Dartigues, JF; Tzourio, C; Alpérovitch, A; Lathrop, M; Feulner, TM; Friedrich, P; Riehle, C; Krawczak, M; Schreiber, S; Mayhaus, M; Nicolhaus, S; Wagenpfeil, S; Steinberg, S; Stefansson, H; Stefansson, K; Snaedal, J; Björnsson, S; Jonsson, PV; Chouraki, V; Genier-Boley, B; Hiltunen, M; Soininen, H; Combarros, O; Zelenika, D; Delepine, M; Bullido, MJ; Pasquier, F; Mateo, I; Frank-Garcia, A; Porcellini, E; Hanon, O; Coto, E; Alvarez, V; Bosco, P; Siciliano, G; Mancuso, M; Panza, F; Solfrizzi, V; Nacmias, B; Sorbi, S; Bossù, P; Piccardi, P; Arosio, B; Annoni, G; Seripa, D; Pilotto, A; Scarpini, E; Galimberti, D; Brice, A; Hannequin, D; Licastro, F; Jones, L; Holmans, PA; Jonsson, T; Riemenschneider, M; Morgan, K; Younkin, SG; Owen, MJ; O'Donovan, M; Amouyel, P; Williams, J

doi:10.1038/ng.803

User: Guest

2011

Back
Back to start of result list
Permanent link for displayed object

Title:: Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Document type:: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Article
Author(s):: Hollingworth, P; Harold, D; Sims, R; Gerrish, A; Lambert, JC; Carrasquillo, MM; Abraham, R; Hamshere, ML; Pahwa, JS; Moskvina, V; Dowzell, K; Jones, N; Stretton, A; Thomas, C; Richards, A; Ivanov, D; Widdowson, C; Chapman, J; Lovestone, S; Powell, J; Proitsi, P; Lupton, MK; Brayne, C; Rubinsztein, DC; Gill, M; Lawlor, B; Lynch, A; Brown, KS; Passmore, PA; Craig, D; McGuinness, B; Todd, S; Holmes, C; Mann, D; Smith, AD; Beaumont, H; Warden, D; Wilcock, G; Love, S; Kehoe, PG; Hooper, NM; Vardy, ER; Hardy, J; Mead, S; Fox, NC; Rossor, M; Collinge, J; Maier, W; Jessen, F; Ruther, E; Schürmann, B; Heun, R; Kölsch, H; van den Bussche, H; Heuser, I; Kornhuber, J; Wiltfang, J; Dichgans, M; Frölich, L; Hampel, H; Gallacher, J; Hüll, M; Rujescu, D; Giegling, I; Goate, AM; Kauwe, JS; Cruchaga, C; Nowotny, P; Morris, JC; Mayo, K; Sleegers, K; Bettens, K; Engelborghs, S; De Deyn, PP; Van Broeckhoven, C; Livingston, G; Bass, NJ; Gurling, H; McQuillin, A; Gwilliam, R; Deloukas, P; Al-Chalabi, A; Shaw, CE; Tsolaki, M; Singleton, AB; Guerreiro, R; Mühleisen, TW; Nöthen, MM; Moebus, S; Jöckel, KH; Klopp, N; Wichmann, HE; Pankratz, VS; Sando, SB; Aasly, JO; Barcikowska, M; Wszolek, ZK; Dickson, DW; Graff-Radford, NR; Petersen, RC; van Duijn, CM; Breteler, MM; Ikram, MA; DeStefano, AL; Fitzpatrick, AL; Lopez, O; Launer, LJ; Seshadri, S; Berr, C; Campion, D; Epelbaum, J; Dartigues, JF; Tzourio, C; Alpérovitch, A; Lathrop, M; Feulner, TM; Friedrich, P; Riehle, C; Krawczak, M; Schreiber, S; Mayhaus, M; Nicolhaus, S; Wagenpfeil, S; Steinberg, S; Stefansson, H; Stefansson, K; Snaedal, J; Björnsson, S; Jonsson, PV; Chouraki, V; Genier-Boley, B; Hiltunen, M; Soininen, H; Combarros, O; Zelenika, D; Delepine, M; Bullido, MJ; Pasquier, F; Mateo, I; Frank-Garcia, A; Porcellini, E; Hanon, O; Coto, E; Alvarez, V; Bosco, P; Siciliano, G; Mancuso, M; Panza, F; Solfrizzi, V; Nacmias, B; Sorbi, S; Bossù, P; Piccardi, P; Arosio, B; Annoni, G; Seripa, D; Pilotto, A; Scarpini, E; Galimberti, D; Brice, A; Hannequin, D; Licastro, F; Jones, L; Holmans, PA; Jonsson, T; Riemenschneider, M; Morgan, K; Younkin, SG; Owen, MJ; O'Donovan, M; Amouyel, P; Williams, J «
Hollingworth, P; Harold, D; Sims, R; Gerrish, A; Lambert, JC; Carrasquillo, MM; Abraham, R; Hamshere, ML; Pahwa, JS; Moskvina, V; Dowzell, K; Jones, N; Stretton, A; Thomas, C; Richards, A; Ivanov, D; Widdowson, C; Chapman, J; Lovestone, S; Powell, J; Proitsi, P; Lupton, MK; Brayne, C; Rubinsztein, DC; Gill, M; Lawlor, B; Lynch, A; Brown, KS; Passmore, PA; Craig, D; McGuinness, B; Todd, S; Holmes, C; Mann, D; Smith, AD; Beaumont, H; Warden, D; Wilcock, G; Love, S; Kehoe, PG; Hooper, NM; Vardy, ER... »
Abstract:: We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P <= 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).
Journal title abbreviation:: Nat Genet
Year:: 2011
Journal volume:: 43
Journal issue:: 5
Pages contribution:: 429-35
Language:: eng
Fulltext / DOI:: doi:10.1038/ng.803
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/21460840
Print-ISSN:: 1061-4036
TUM Institution:: Institut für Medizinische Statistik und Epidemiologie
BibTeX

Occurrences:

mediaTUM Gesamtbestand Hochschulbibliographie 2011 Fakultäten Medizin Institut für Medizinische Statistik und Epidemiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2011